The next martyr was a man named George Wishart. He also had studied Reformed Theology on the Continent. He was responsible for teaching the Greek New Testament. This conflicted with the Catholic Church. With all the threats he was facing, Wishart began to travel with a body guard. The man who was constantly at his side, wielding a double-handed sword, was named John Knox. Eventually Wishart was betrayed into the hands of Cardinal Beaton. Beaton tried Wishart for heresy and condemned him to death. Knox volunteered to die alongside Wishart but Wishart told Knox that he had work to do yet.

It was the spring of 1547 when Protestant nobles took the castle in St Andrews. They had had enough of the tyranny of the Catholic Church. They were later joined by John Knox and persuaded him to become their minister. Up until then he had only been a teacher despite his close relationship with George Wishart. The Protestants dug in and waited for the inevitable attack. The Catholic forces brought in reinforcements from France but were unable to break into the castle for some time. Finally, the Protestants surrendered under the understanding that all within the castle were given life and liberty. The Catholic forces did not honor these terms and the prisoners, Knox included, became galley slaves in the French vessels.